Atlas of Biomarker Candidates (ABC)
Updated
— Proteins
— Traits
23 Categories
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Type to search across 1,090 biomarker entries — or browse by disease category below.
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Protein Interaction Network

Interaction data from STRING-DB (v12, human). 537 atlas proteins · 5,373 interactions. Node size = diseases implicated. Color = primary disease category.

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Building network…
31 Jul 2026
v2.8 — Weekly digest update (3 new proteins)
  • +3 entries: ITGAM, VWF, AKR1B10 — 1,087 → 1,090 total
  • ITGAM (integrin alpha-M / CD11b) — consistently reduced in dementia with Lewy bodies vs AD/FTD, correlates with autopsy-confirmed α-synuclein pathology; part of a 21-protein plasma panel for differential dementia diagnosis and staging (bPRIDE study, Nature Aging 2026).
  • VWF (Von Willebrand Factor) and AKR1B10 — diagnostic biomarkers for advanced (F3–F4) NAFLD fibrosis, individually AUC 0.777 and 0.733, combined 4-protein panel (with already-tracked THBS2 and NFASC) AUC 0.860–0.880 (J Inflamm Res 2026).
  • ⭐ Flagged high priority: "Plasma proteomic signatures of cellular aging predict human disease" (Nature Medicine 2026) — cell-type-resolved (40+ cell types) plasma aging clocks in 60,542 individuals; no new discrete protein (composite ML score) but directly relevant to SYN-WAVE roadmap.
  • Sections searched with no new proteins: lung cancer (corroborating validations only), other/colorectal cancers, cardiovascular, metabolic/diabetes/endocrine, respiratory, inflammatory/haematological, infectious, musculoskeletal/eye/gynaecological, methods/platforms, psychiatric (JAM3 corroboration only, already tracked).
  • Atlas redeployed to production
3 Jul 2026
v2.7 — Weekly digest update (2 new proteins)
  • +2 entries: ADA, CTSS — 1,085 → 1,087 total
  • ADA (adenosine deaminase) — elevated in IPF; part of a 4-protein plasma inflammation-panel signature (FGF-19, MMP-10, ADA, TWEAK) separating IPF from CTD-ILD, GLM AUC 0.870 (Respiratory Research 2026).
  • CTSS (cathepsin S) — proteome-wide MR + colocalization links higher plasma CTSS to increased schizophrenia risk; replicated across deCODE, Fenland, UKB-PPP and GTEx brain eQTL (Frontiers in Psychiatry 2026).
  • Sections searched with no new proteins: organ aging/exposome, lung cancer, other/colorectal cancers, neurodegeneration, cardiovascular, metabolic, inflammatory/haematological, renal/hepatic/GI, infectious, musculoskeletal/eye/gynaecological, methods/platforms.
  • Atlas redeployed to production
29 May 2026
v2.6 — Weekly digest update (1 new protein)
  • +1 entry: JAM3 — 1,084 → 1,085 total
  • JAM3 (Junctional Adhesion Molecule-3): causal MR biomarker for schizophrenia (β=0.146, p=0.004); LightGBM AUC=0.793; UKB N=70 cases / 36,135 controls; Translational Psychiatry 2026
  • Sections searched: Organ Aging (exercise reversal of proteomic aging, npj Aging 2026; PAOPAC bioRxiv), Lung Cancer (Bhardwaj Mol Oncol 2026; CommsMed proteogenomic ML), Other Cancers (pan-cancer NBE 2026; composite proteomic/metabolomic panel), Neurodegeneration (Global Neurodegeneration Proteomics Consortium, Nat Med 2026; AD/PD subtypes), CVD (HF+PH serum proteomics), Respiratory (IPF vs CTD-ILD ML), Inflammatory/Immune (psoriasis longitudinal proteomics secukinumab), Psychiatric (schizophrenia JAM3 MR), Infectious Disease (sepsis biomarkers review), Methods (pSIN 51-protein smoking index AUC=0.95; HEAP exposome framework)
  • Atlas redeployed to production
22 May 2026
v2.5 — Weekly digest update (3 new proteins)
  • +3 entries: LEP, FABP4, FGF21 — 1,081 → 1,084 total
  • LEP (Leptin): HEAP study exercise-responsive plasma protein; T2D & CVD risk mediator; N=53,014 UKB
  • FABP4: HEAP study exercise-responsive adipokine; links adipose tissue to CVD/metabolic risk
  • FGF21: HEAP study diet-responsive metabolic regulator; lipid metabolism mediator; distinct from FGF23
  • Sections searched: Organ Aging (PAOPAC preprint, longitudinal midlife clocks, HEAP study), Lung Cancer, Other Cancers, Neurodegeneration (ProtAIDe-Dx Nature Medicine), CVD (AF-HF biomarkers), Metabolic, Respiratory, Inflammatory/Immune, Renal/GI, Psychiatric, Infectious, Musculoskeletal/Eye/Gyn, Methods & Platforms
  • Atlas redeployed to production
15 May 2026
v2.4 — Weekly digest update (2 new proteins)
  • +2 entries: PTX3, CCL19 — 1,079 → 1,081 total
  • PTX3 (Pentraxin-3): NSCLC 4-protein OS signature (CEACAM5+PTX3+FGF23+AREG); npj Precision Oncology 2026
  • CCL19: NSCLC ICI non-responder baseline marker; nELISA-validated; npj Precision Oncology 2026
  • Sections searched: Organ Aging, Lung Cancer, Other Cancers, Neurodegeneration, CVD, Metabolic, Respiratory, Inflammatory/Immune, Renal/GI/Hepatic, Psychiatric, Infectious, Musculoskeletal/Eye/Gynaecological, Methods & Platforms
  • Atlas redeployed to production
14 May 2026
v2.3 — Weekly digest update (7 new proteins)
  • +7 entries: RACGAP1, RBFOX3, NAMPT, NNMT, PARP9, DPEP1, PTPRR — 1,072 → 1,079 total
  • RACGAP1: AF-specific circulating biomarker in HF (Circulation AE, 2026; dual-cohort)
  • RBFOX3: Novel plasma biomarker for ovarian cancer malignancy detection (Sci Reports, 2024)
  • NAMPT / NNMT / PARP9: UC NAD+ metabolism subtype diagnostics (Frontiers Immunol, 2026)
  • DPEP1: Pan-cancer ML biomarker shared across CRC & prostate (PMC, 2026)
  • PTPRR: Top organ aging clock protein across 40+ cell types, 60k individuals (bioRxiv, Feb 2026)
  • Atlas redeployed to production
Apr 2026
v2.2 — DDC annotation (with caveats)
  • +1 entry: DOPA Decarboxylase (DDC) added to Parkinson’s Disease with critical treatment caveat
  • Plasma DDC elevated in treated PD only — NOT in de novo/untreated patients (p=0.128–0.233)
  • Bolsewig et al. 2025 (Nat Commun, N=1,635); Pereira et al. 2023 (Nat Aging)
  • Total: 1,072 entries; 78 proteins in PD category
Apr 2026
v2.1 — Literature expansion (9 papers)
  • +60 new biomarker entries; +41 new gene symbols (692 → 748 unique proteins)
  • Parkinson’s Disease: 11 proteins — Homann et al. 2025 (SomaScan-7K, N=74,000)
  • Colorectal Cancer: 15 proteins — Sun et al. 2024 (Olink, UKB N=52,231)
  • Type 2 Diabetes: 9 proteins — Ngo et al. 2021 & Huth et al. 2018
  • Heart Failure: 7 proteins — Emilsson et al. 2024 (SomaScan V3-5K, N=5,457)
  • Brain/Organ Aging: 7 proteins — Lehallier et al. 2023 (SomaScan v4, N=5,676)
  • Acute MI & CVD: 9 proteins — Beck et al. 2024 & Lassé et al. 2021
  • Depression: 2 proteins — Zhang et al. 2025 (Olink, N=412)
  • 7 existing entries updated with replication notes (ADIPOQ, SHBG, HPGDS, NPPB, TNNT2, COL9A1, CRTAC1)
Early 2026
v2.0 — Atlas launch
  • 1,011 entries across 22 disease categories; 692 unique proteins
  • Protein Interaction Network, Strategic Assessment, Nomic panel filter
  • Disease-specific and pleiotropic protein views